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Analysis of methylation status has shown to be important for the understanding of diverse biological processes. Also, recently methylation specific PCR has gained traction in the molecular diagnostics arena for such diverse areas as cancer, metabolic disease and behavioral disorders. As clinical researchers identify methylation specific biomarkers for these key clinical areas, more diagnostic system will need to be able to support methylation specific PCR tests.
With the ICEPlex system clinical researchers can very easily design and run assays for methylation status of specific genes. Also, since the ICEPlex system allows multi target type assays, it is possible to design assays that define the methylation status as well as the expression as well as the mutational status all in one well.
We have performed numerous experiments to demonstrate the capabilities of the ICEPlex System in methylation analysis. In one experiment, we showed that we can distinguish between the methylated and unmethylated sequences after bisulfate conversion, by amplicon sizes.