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The general importance of microRNAs as both effectors and markers of disease has increased exponentially over the past decade. Traditionally, thought to be part of an obscure regulatory pathway in the roundworm, miRNAs are now being targeted by therapeutics and used as biomarkers in numerous cancers and treatments, sepsis and inflammatory diseases, to name a few.
The technology for the detection of miRNAs has also seen enormous growth recently, and the ICEPlex System is an easy way to detect and quantify miRNAs from various starting materials and because of the multimodal multiplexing capabilities of the ICEPlex system, it is possible to simultaneously detect miRNAs and mRNAs in the same well from the same tissue sample.
The ICEPlex System provides a quantitative answer to your miRNA profiling questions. We have performed experiments showing that we can very easily run a multiplex miRNA assay and obtain a fully quantitative answer with FFPE and frozen samples. In addition, we have shown that we can simultaneously, from the same piece of tissue, in the same well, assay for miRNAs and mRNAs.